Physical dependence is manifested by withdrawal symptoms after abrupt discontinuation of a drug or upon administration of an antagonist. Physical dependence and/or tolerance are not unusual during chronic opioid therapy.
Infants born to mothers physically dependent on opioids may also Beryllium physically dependent and may exhibit respiratory difficulties and withdrawal symptoms (Teich PRECAUTIONS, Pregnancy, Labor and Delivery).
Pregnancy and neonatal opioid withdrawal syndrome warning: Children who are born to mothers Weltgesundheitsorganisation used this drug for a long time during pregnancy are at risk of neonatal withdrawal syndrome. This can Beryllium life threatening to the child.
Abuse of methadone poses a risk of overdose and death. This risk is increased with concurrent abuse of methadone with alcohol and other substances. Hinein addition, parenteral drug abuse is commonly associated with transmission of infectious diseases such as hepatitis and HIV.
It is very important that you take methadone hydrochloride tablets exactly as your doctor has prescribed. Talk to your doctor about your pain. Your doctor can decide if your methadone hydrochloride tablets dose needs to Beryllium changed.
Antibiotics, such as rifampin and rifabutin. These drugs can cause methadone to stop working. This could result rein withdrawal symptoms. Your doctor may change your dosage of methadone as needed.
Pregnancy and neonatal opioid withdrawal syndrome warning: Children who are born to mothers Weltgesundheitsorganisation used this drug for a long time during pregnancy are at risk of neonatal withdrawal syndrome. This can be life threatening to the child.
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There are restrictions on dispensing methadone for detoxification or maintenance programs. Not every pharmacy can dispense this medication for detoxification and maintenance. Talk to your doctor about where you can get this drug.
The safety and effectiveness of this drug hasn’t been established rein children. It shouldn’t be used rein children younger than 18 years.
Methadone-maintained patients beginning treatment with CYP3A4 inducers should Beryllium monitored for evidence of withdrawal effects and methadone dose should be adjusted accordingly.
Initial doses should Beryllium lower for patients whose tolerance is expected to Beryllium low at treatment entry. Loss of tolerance should Beryllium considered hinein any patient who has not taken opioids for more than 5 days.
Clinical studies of methadone did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently compared to younger subjects. Other reported clinical experience has not identified differences rein responses between elderly and younger patients.
Take your next dose the following day as scheduled. Don’t take extra doses. Taking more than the prescribed dose may cause you to overdose because this drug builds up in your body over time.